The CISS Effect on Science Magazine

Separation of enantiomers by their enantiospecific interaction with achiral magnetic substrates

Kiralis was founded for developing and  commercializing a technology based on the discovery and successful proof of concept by Prof. Ron Naaman of The Weizmann Institute of Science and Prof. Yossi Paltiel of Hebrew University of Jerusalem that discovered a phenomenon they defined chiral-induced spin selectivity (CISS).

In an Article published on Science on May 2018 they’ve shown how CISS could be exploited to separate enantiomers in a racemic mixture, by application of a magnetic directional force.

Abstract from Science Magazine

It is commonly assumed that recognition and discrimination of chirality, both in nature and in artificial systems, depend solely on spatial effects. However, recent studies have suggested that charge redistribution in chiral molecules manifests an enantiospecific preference in electron spin orientation. We therefore reasoned that the induced spin polarization may affect enantiorecognition through exchange interactions. Here, we show experimentally that the interaction of chiral molecules with a perpendicularly magnetized substrate is enantiospecific. Thus, one enantiomer adsorbs preferentially when the magnetic dipole is pointing up, whereas the other adsorbs faster for the opposite alignment of the magnetization. The interaction is not controlled by the magnetic field per se, but rather by the electron spin orientations, and opens prospects for a distinct approach to enantiomeric separations.

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We commissioned Irish Creative agency Think Visual to make an animation explaining The CISS Effect and it’s potential contribution for producing safe chemicals. It was used in Science Magazine.

Arie Laor